This very important piece of research initiated in 1980 until 2012 (i.e. 32 years), following the dietary intake, lifestyle and disease relation for a total of 83, 349 women (from the Nurse’s Health Study) and 42, 884 men (from the Health Professionals Follow-up Study).
The aim was to identify the long term associations between dietary intake of specific fats and mortality.
It showed that replacing saturated fatty acids (SFAs) with the same energy from poly-unsaturated fatty acids (PUFAs) was associated with a lower risk for mortality due to Cardiovascular Heart Disease (CVD), cancer and neurogenerative diseases (such as Alzheimer’s disease). Replacement of 5% of energy from SFAs with 5% of energy from mono-unsaturated fatty acids (MUFAs) was associated with a 29% estimated reduction in neurogenerative disease mortality.
This high-quality epidemiologic study supports our IMACE Position on SFA and PUFA and reinforces the current dietary recommendations to replace saturated fat by unsaturated fats.
Reference: Dong D Wang, Yanping Li, Stephanie E. Chiuve, Meir J. Stampfer, Harvard T.H. Chan Sch of Public Health, Boston, MA; JoAnn E. Manson, Harvard Medical Sch, Boston, MA; Eric B. Rimm, Walter C. Willett, Frank B. Hu, Harvard T.H. Chan Sch of Public Health, Boston, MA. Association of specific dietary fats with total and cause-specific mortality. JAMA Intern Med. 2016;176(8):1134-1145.
You may find the abstract here: Wang et al., 2016.